Col. U.S.A. (R), U.S.A.F, M.C. (Ret)
Founder, President American Academy of Medical Detectives (AAOMD)
3708 N Loyola Dr, Kenner. LA. Apt 115.
Kenner, LA 70065
504-583-4593
Circa 2008, oral Phosphodiesterase Type-5 inhibitors, after many years, and many studies, under FDA rules, were found to have many beneficial uses. This type of ‘medication’ was most beneficial in the metabolism and oxidative phosphorylation and initiator of good health and healing.The first approval by the FDA was for Erectile Dysfunction. A gold mine had been found!
Such approval was for one aspect, of the studies and investigations. A coincidental pharmaceutical gold mine resulted. Fortunately, the studies opened many eyes, and led to new treatments for multiple other diseases and disorders, now turning out to be quite beneficial.
The four major drugs, by multiple investigators, have similarities and slight differences. This report involves one, Tadalafil. This agent appears to be the safest one, and has the longest half-life, and a low dosage regimen.
So far, after approximately four years of continual use, it appears quite safe.
All of these drugs work to improve function on smooth muscle tissue, the target area. Smooth muscle is part of the anatomy of blood vessels and organs. The main action is to improve vascular and endothelial function. Every area and organ of the human body is involved.
Tadalafil (Cialisc), is obviously beneficial and very helpful for Erectile Dysfunction, male and female, and Benign Prostatic Hyperplasia and hormone control by regulation of hormone production and release. Good smooth muscle function is necessary for effective hormone function.
All blood vessels rely on healthy smooth muscle for effective function, including brain, heart, lungs, and visceral organs and mesentery, and fat tissue vessels.
Particular benefit has been noticed for heart and retinal vessels. Benefits have also been noted in pulmonary and portal hypertension control.
Another gold mine is on the horizon, as Tadalafil may prove very effective for migraines! Smooth muscle tone can stabilize and relax the migraine foci, without need for toxins (Botox)
There is no major/overt contraindication except with nitrous oxide medications concurrently. Priapism is possible, but may be anecdotal and subliminally effective advertisement.
There are many other prospective uses, including treatment of diabetes, chronic colitis, endometriosis, esophagitis/heartburn, fibromyalgia, scleroderma, lupus erythematosus, and the list goes on.
There is great promise for the oral Phosphodiesterase Type-5 inhibitors.
References.
Nonerectogenic Beneficial Uses, J. Sex Med 2008, et al.